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Interaction of plakophilins with desmoplakin and

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Desmoplakin - wikid

Desmoplakin exists as two predominant isoforms; the first, known as "DPII", has molecular weight 260.0 kDa (2272 amino acids) and the second, known as "DPI", has molecular weight 332.0 kDa (2871 amino acids). These isoforms are identical except for the shorter rod domain in DPII. DPI is the predominant isoform expressed in cardiac muscle.

Defining the Interactions Between Intermediate Filaments .

Defining the Interactions Between Intermediate Filaments and Desmosomes. Elizabeth A. Smith, Elaine Fuchs ... plakophilins seem to be localized more distantly from the midline of the desmosome ... DPII, and Dsg1 (165 kD) migrated at these positions. The interaction between PG and desmoplakin had been detected, although it was weak, in the ...

Plakophilins: Multifunctional proteins or just regulators .

Read "Plakophilins: Multifunctional proteins or just regulators of desmosomal adhesion?, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

desmoplakin - medd

Genetic screening of major ARVC-causing desmosome genes (junction plakoglobin, desmoplakin, plakophilin-2, desmoglein-2, and desmocollin-2) identified 2 novel which ...

desmoplakin I/II shRNA Plasmid (m): sc-45911-

desmoplakin is the most abundant. Desmoplakin plays an important role in the attachment of the filaments to the desmosome. Specifically, desmoplakin interacts with plakophilin 1 (PKP1), PKP2 or PKP3, or combinations thereof, to selectively recruit plakophilins to desmosomal plaques. Desmoplakin has also

Defining desmosomal plakophilin-3 interactions .

As such, this is the first protein interaction ever observed with a Dsc-b isoform. Moreover, we determined that PKP3 interacts with plakoglobin, desmoplakin (DP) and the epithelial keratin 18. Evidence was found for the presence of at least two DP-PKP3 interaction sites.

Desmoglein 3, via an Interaction with E-cadherin, Is .

Desmoglein 3, via an Interaction with E-cadherin, Is Associated with Activation of Src. Siu Man Tsang, Affiliation: Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Queen Mary University of London, Barts and The London School of Medicine and Dentistry, London, United Kingdom ... via an Interaction with E-cadherin, Is ...

Plakins: a family of versatile cytolinker proteins: Trends .

Plakins are cytolinker proteins that associate with cytoskeletal elements and junctional complexes. Seven plakin family members have been identified: desmoplakin, plectin, bullous pemphigoid antigen 1 (BPAG1), microtubule–actin crosslinking factor (MACF), envoplakin, periplakin and epiplakin ().This family of proteins is defined by the presence of a plakin domain and/or a plakin repeat ...

Are desmosomes more than tethers for intermediate .

Are desmosomes more than tethers for intermediate filaments? ... Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis. J.

Interaction of plakophilins with desmoplakin and .

We postulate that (1) effective cellular regulatory mechanisms exist that prevent plakophilins from unscheduled IF-binding, and (2) specific desmoplakin interactions with either PKP1, PKP2 or PKP3, or combinations thereof, are involved in the selective recruitment of plakophilins to the desmosomal plaques.

Plakophilin-1 - Wikiped

Function. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton.

anti-Desmoplakin 1/2 mouse monoclonal, DP-2.15 + DP-2.17 .

Hofmann, I. et al. Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis. J. Cell Sci. 113, 2471–83 (2000). human IP Chitaev, N. A. et al. The Binding of Plakoglobin to Desmosomal Cadherins: Patterns of Binding Sites and Topogenic Potential. J. Cell Biol. 113, 359–369 (1996).

Plakophilin-1 Localizes to the Nucleus and Interacts with .

Plakophilins (Pkp-1, -2, and -3) comprise a family of armadillo repeat–containing proteins first identified as desmosomal plaque components, in which they link desmoplakin to the desmosomal cadherins. In addition to their role in desmosomal cell–cell adhesion, Pkps also localize to the nucleus, where they perform unknown functions.

Plakoglobin but Not Desmoplakin Regulates Keratinocyte .

Plakoglobin but Not Desmoplakin Regulates Keratinocyte Cohesion via Modulation of p38MAPK Signaling Volker Spindler1,3, Carina Dehner1,3, Stefan Hu¨bner2 and Jens Waschke1 Plakoglobin (Pg) and desmoplakin (DP) are adapter proteins within the desmosome, providing a mechanical

Protein Binding and Functional Characterization of .

Plakophilins are a subfamily of p120-related arm-repeat proteins that can be found in both ... including desmoplakin, plakoglobin, desmoglein 1 and 2, and desmocollin 1a and 2a. ... which is consistent with the weaker interaction observed between PKP2 and DP and indicates

Anti- Desmoplakin 1/2 antibody - progen.c

Mouse monoclonal anti- desmoplakin 1/2 antibody suitable for ICC, IHC and WB. ... R. et al. Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins. ... I. et al. Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis. J. Cell Sci. 113, 2471–83 (2000). ...

The Armadillo Family Protein p0071 Is a VE-cadherin- and .

Abstract. p0071, a member of the armadillo protein family, localizes to both adherens junctions and desmosomes in epithelial cells and exhibits homology to the adherens junction protein p120 and the desmosomal protein plakophilin-1. p0071 is also present at dermal microvascular endothelial intercellular junctions and colocalizes with VE-cadherin, an endothelium-specific cadherin that ...

Extracellularly truncated desmoglein 1 compromises .

Plakophilins (PPs) and Desmoplakin (DP). Previous studies on desmosome-mediated adhesion have focused on the intracellular domains of Dsc and Dsg because of ...

Desmoplakin : Wikis (The Full Wik

Desmoplakin is a protein associated with desmosomes. [1] Desmoplakin is a protein that in humans is encoded by the DSP gene. [2] [3] ...

Interaction of plakophilins with desmoplakin ... - Wikida

Interaction of plakophilins with desmoplakin and ... edit. Language Label Description Also known as; English: Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis. scientific article. Statements. instance of. scholarly article. 0 references. title. Interaction of plakophilins with desmoplakin and ...

Plakophilin-1 — Wikipedia Republished // WIKI

Plakophilin-1. Quite the same Wikipedia. Just better. Hatzfeld M, Kristjansson GI, Plessmann U, Weber K (1995). "Band 6 protein, a major constituent of desmosomes from stratified epithelia, is a novel member of the armadillo multigene family".